![]() Aromatase inhibitors are not intended for preventing breast cancer recurrence if you still have menstrual cycles.Īromatase inhibitors, specifically exemestane and anastrozole, have also been studied to see if they may reduce the risk of breast cancer in people at high risk, such as those with a family history of breast cancer or a history of precancerous breast lesions. Who they're forĪromatase inhibitors have been studied and shown to be effective to treat breast cancer and to prevent breast cancer recurrence after menopause. These medications are used to treat breast cancer that's estrogen- or progesterone-responsive in those who've undergone menopause. Three aromatase inhibitors are currently approved in the United States for breast cancer treatment: anastrozole (Arimidex), exemestane (Aromasin) and letrozole (Femara). For this reason, raloxifene may be a preferred option if you've undergone menopause and haven't had a hysterectomy or have osteoporosis. ![]() But if you have heart disease or you have multiple risk factors for heart disease, raloxifene may increase your risk of strokes.Īlthough tamoxifen may be slightly better than raloxifene at reducing the risk of breast cancer, the risk of blood clots and uterine cancer are lower with raloxifene. Raloxifene may also be linked to fewer strokes than tamoxifen in people at average risk of heart disease. Raloxifene may be associated with fewer instances of endometrial and uterine cancers than is tamoxifen. Health risks associated with raloxifene are similar to those associated with tamoxifen.īoth drugs carry an increased risk of blood clots, though the risk may be lower with raloxifene. Common side effectsĬommon side effects of raloxifene include: Raloxifene is also used for prevention and treatment of the bone-thinning disease osteoporosis in those who've undergone menopause. You're considered at high risk if you score greater than 1.7% on the Gail model. Raloxifene is used to reduce the risk of invasive breast cancer if you're at high risk and you've undergone menopause (postmenopausal). If you've undergone menopause, the benefits of tamoxifen may outweigh the risks if you have an increased risk of breast cancer and have also had surgery to remove your uterus (hysterectomy). In this situation, the benefits of tamoxifen may outweigh the risks if you have an increased risk of breast cancer due to a strong family history or a personal history of precancerous breast changes. If you haven't undergone menopause, the risk of uterine cancer when taking tamoxifen is very low compared with the risk for those who have already undergone menopause. You don't have a history of blood clots.Ĭommon side effects of tamoxifen include:.You have a strong family history of breast cancer.For instance, you've had a breast biopsy that found a precancerous condition such as lobular carcinoma in situ, atypical ductal hyperplasia or atypical lobular hyperplasia. You're at high risk of developing breast cancer.The risk score is based on factors such as age, reproductive history and family history. ![]() The Gail model is a tool that health care providers use to predict future risk of developing breast cancer.
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